Renal colic – the twinkle artifact

Images Bashir Antoine Chakar, text Genevieve Carbonatto

A 32 year old man presents with right flank pain. He had an episode of renal colic 2 years ago and presented to the Emergency Department back then. He had a CT KUB done at the time which showed a small stone in his right VUJ and a larger 7mm stone in his right renal calyx. He is in agony and cannot lie still. You give him opiates and nonsteroidal antiinflammatories. When his pain settles a little you do a focussed bedside ultrasound. Below is his right kidney and left kidneys taken longitudinally


The right kidney is 10.3cm in length and his left kidney is 10.4 cm. Note the large 14 mm stone in the pelvis of his right kidney.

Note that there is no hydronephrosis. This is more evident on the transverse view of the kidney

An examination of the bladder shows an echogenic foci which appears to be in the right VUJ, which, with colour Doppler shows a twinkling artifact. The echogenic focus is not producing an acoustic shadow and therefore it is difficult to be sure that this is a stone. The twinkle artifact, which is the colour Doppler signal behind the echogenic foci confirms that this is indeed a stone


Why use Colour Doppler to help identify stones and what is the twinkling artifact?

Sonography of the renal tract to look for stones is not as sensitive or as specific as CT scanning. We have seen this in a previous post. The great advantage however is that sonography does not irradiate the patient especially in a group of patients who tend to have multiple CTs for the same pathology. In an uncomplicated case of renal colic, an ultrasound can help with diagnosis and disposition. Unfortunately, the visualisation of stones with ultrasound is operator dependent and therefore the sensitivity ranges between 19 -93%  with a specificity of 84 -100%. Experienced radiologists attain the highest sensitivities and specificities for the identification of stones. When stones are small they may not produce characteristic posterior shadowing. This is due to spatial compounding which creates shadows at different angles that are averaged (1) Using colour Doppler to look for the twinkling artifact improves the ability to confirm the presence of small stones especially if an acoustic shadow is not present. The twinkling artifact was first descibed by Rahmouli et al in 1996 (3)

This artifact is associated with several characteristics (2)

  • It is a focus of alternating colours on Doppler signal
  • It is seen behind a reflective surface (such as a calculus)
  • It has the appearance of turbulant blood flow
  • It appears with or without a comet tail artifact
  • It is more sensitive (47.6 % to 86% in one study (4))and specific (1) for detection of small stones than is acoustic shadowing.
  • It is more pronounced when the reflective surface is rough
  • It is dependent on the location of the focal zone. When the focal zone is located below a rough reflective surface, the twinkling artifact becomes more pronounced.

Not all stones produce a twinkling artifact. Rough surfaced rather than smooth surfaced stones produce this artifact (5)

With our patient, colour Doppler behind the larger 14mm stone produced a colour artifact that resembled turbulent, aliasing / mosaic, blood flow.

This has been observed in previous studies (7) as a potential misdiagnosis of blood flow. 2 D  imaging was clearly sufficient in this case to diagnose the large renal calculus.

On the other hand, the twinkle artifact produced by the small non-shadowing stone in the VUJ was helpful in confirming the presence of the stone.

What causes the twinkling artifact?

It is not yet clear what is the cause of the twinkling artifact. Several papers have been published which try to address this issue. The following comments are by Robert Gill, author of  “The Physics and Technology of Diagnostic Ultrasound: A Practitioner’s Guide” regarding the origin of the twinkling artifact:

I’ve come across four different theories, none of which seems to be widely regarded as the leading contender. They are:
– the key thing is that the structure causing the artifact has a rough surface;
– the cause is “phase jitter” in the machine’s electronics (this seems improbable to me);
– the cause is small gas bubbles trapped on the rough surface (this comes from Jonathan Rubin’s group and doesn’t seem to be widely embraced by others);
– the cause is movement of the structures due to ultrasound radiation force.

My guess is that the first of these is correct, and that slight movement of the stone (or other structure) causes significant changes of the echo signal (because of the rough surface). The machine misinterprets these changes as random Doppler shifts. The movement may be caused by the patient’s respiration and transmitted arterial pulsation and/or slight unconscious movements of the probe. Radiation force may also cause movement.

Teaching point: The twinkle artifact improves sensitivity and specificity for the detection of small renal calculi. This is especially true if the calculus is not associated with acoustic shadowing. It is worth remembering however, that not all renal stones will be associated with a twinkle artifact. Stones which have a rough surface will produce a twinkle artifact while smoother stones may not.


  1. J Endourol 2013 Feb; 27(2): 149–153.doi: 10.1089/end.2012.0430PMCID: PMC3573723B-mode Ultrasound Versus Color Doppler Twinkling Artifact in Detecting Kidney Stones Mathew D. Sorensen, MD, MS,corresponding author1 Jonathan D. Harper, MD,1 Ryan S. Hsi, MD,1 Anup R. Shah, MD,1 Manjiri K. Dighe, MD,2 Stephen J. Carter, MD,2 Mariam Moshiri, MD,2 Marla Paun, BS, RDMS, RVT,3 Wei Lu, MS,3 and Michael R. Bailey, PhD3
  2. Radiopaedia Dr Saeed Soltane Hosn The twinkle artifact
  3. Radiology. 1996;199:269–271. Rahmouni A. Bargoin R. Herment A, et al. Color Doppler twinkling artifact in hyperechoic regions.
  4. Abdom Imaging. 2013;38:863–869. doi: 10.1007/s00261-012-9946-7.Ripollés T, Martínez-Pérez MJ, Vizuete J, et al. Sonographic diagnosis of symptomatic ureteral calculi: usefulness of the twinkling artifact.
  5. AJR Am J Roentgenol. 2003;180:215–222 Kamaya A. Tuthill T. Rubin JM. Twinkling artifact on color Doppler sonography: Dependence on machine parameters and underlying cause.
  6. Int Braz J Urol. 2009;35:532–541. Mitterberger M. Aigner F. Pallwein L, et al. Sonographic detection of renal and ureteral stones. Value of the twinkling sign.
  7.  J Clin Ultrasound. 1999;27:433–439. Aytac SK. Ozcan H. Effect of color Doppler system on the twinkling sign associated with urinary tract calculi.



Leave a Reply

Your email address will not be published. Required fields are marked *

Protected with IP Blacklist CloudIP Blacklist Cloud